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The Big Key Skip requires doing Portal Items with the Mole Mitts at the Minish Portal on the third floor. Place a bomb above the portal and perform Portal Items (hold up+right/left, use Mole Mitts and wait till you hit the portal with them, hold right/left) (note: The closer you are to the top of the portal when you jump on the better. If you're too low, you won't be able to clip). Once you've preformed it, wait until the third bomb flash (the third flash is one frame so it's easy to miss!) and start pausing and unpausing until you are on one of the good frames shown below:
Third flash (bad frame):------------------Inbetween frame 1 (good):---------------Inbetween frame 2 (good):---------------Inbetween frame 3 (good):--------------Inbetween frame 4 (good):---------------Fourth flash (good*):
*The fourth flash sometimes doesn't work. Your best bet is the 4 inbetween frames.
Once you've paused on the correct frame start holding up and unpause. You should jump off the portal and the bomb will boost you out of bounds. After going OoB, head to the room to the left and jump off of the top door frame to put you on the correct layer and proceed to the boss.
If you go directly to the boss room after going OoB, you'll softlock the game so make sure to go to the room to the left before entering the boss room.
(Videos when ready.)
It is possible while having one hand stunned to place yourself close enough in the palm to have the other hand not be able to hit you
The pillar with the eye in Mazaal's head is never in the same place two times in a row. Use this to route your digging for the 5 other pillars effectively.